SPRAVATO® (Esketamine) Therapy for Severe Depression

Find Rapid Relief for Treatment-Resistant Depression

If you’ve struggled with severe depression and haven’t found relief with traditional antidepressants, you’re not alone. At NeuroHealth Treatment Centers, we offer SPRAVATO® (esketamine)—a fast-acting, FDA-approved treatment for treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal thoughts. Unlike standard antidepressants, which can take weeks to work, SPRAVATO® may provide noticeable symptom relief in just hours to days.

SPRAVATO® must be administered in a clinical setting. Make an appointment with NeuroHealth Treatment Centers today by calling 954-417-7575. Based in Fort Lauderdale, our team serves patients throughout South Florida.

One of the BEST TMS centers in the state of Florida! The staff is so welcoming and their office space brings a homey and zen atmosphere. I recently, had the pleasure of listening to Dr. Kessler speak at a Panel on Depression + Anxiety and was beyond impressed. If you’re looking for psychiatric services, Spravato treatment, or TMS and individual therapy, this is the perfect place to start your journey!

– Tracy O.

What Is SPRAVATO®?

SPRAVATO® is a nasal spray medication derived from ketamine, a well-known anesthetic with rapid antidepressant effects. Unlike traditional antidepressants that target serotonin and dopamine, SPRAVATO® works on the NMDA receptors in the brain, helping to restore neural connections linked to mood and emotional regulation.

SPRAVATO® is FDA-approved for:

• Treatment-resistant depression (TRD) – for patients who have tried two or more antidepressants without success.
• Major depressive disorder (MDD) with suicidal ideation – for those experiencing severe symptoms, including thoughts of self-harm.

Important: SPRAVATO® is not a take-home medication. It must be administered in a certified treatment center under medical supervision.

How Does SPRAVATO® Work?

Unlike conventional antidepressants that can take weeks to become effective, SPRAVATO® starts working within hours to days for many patients. It affects glutamate, the most abundant neurotransmitter in the brain, to rapidly improve mood, energy levels, and cognitive function.

How SPRAVATO® Is Administered

• SPRAVATO® is a nasal spray that you self-administer under the guidance of our medical team.
• After taking the dose, you’ll stay in our comfortable treatment center for about two hours for monitoring.
• Treatment is typically scheduled twice a week for the first month, then gradually reduced.

Many patients report feeling relief from depressive symptoms after just a few sessions.

How Is SPRAVATO® Different from Ketamine?

While both SPRAVATO® (esketamine) and ketamine have rapid antidepressant effects, there are key differences between the two treatments. Understanding these differences can help you determine the best option for your mental health care:

FDA Approval & Medical Use

• SPRAVATO® is FDA-approved specifically for treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal ideation.
• Ketamine infusions are off-label treatments used for depression, anxiety, and chronic pain but are not FDA-approved for depression.

Method of Administration

• SPRAVATO® is a nasal spray that must be administered under medical supervision at a certified treatment center.
• Ketamine is typically administered as an intravenous (IV) infusion or intramuscular injection in various clinical settings.

Chemical Differences

• SPRAVATO® contains esketamine, a specific form of ketamine that is more potent and targeted in its action.
• Traditional ketamine contains both esketamine and arketamine, which may affect individuals differently.

Monitoring & Safety

• SPRAVATO® requires two hours of monitoring after administration due to potential side effects such as dissociation and dizziness.
• Ketamine infusions also require monitoring, but treatment guidelines vary by provider.

Insurance Coverage

• SPRAVATO® is often covered by insurance for eligible patients with TRD or MDD.
• Ketamine infusions are typically not covered by insurance, making them a more expensive out-of-pocket option.

NeuroHealth Treatment Centers only offers SPRAVATO® (esketamine) therapy for depression. We can assess your medical history, medications, and other factors to determine if SPRAVATO® is right for you.

Am I a Candidate for SPRAVATO®?

You may be eligible for SPRAVATO® if you:

• Have been diagnosed with treatment-resistant depression (TRD) (failed two or more antidepressants)
• Have major depressive disorder (MDD) with suicidal ideation
• Are currently taking an oral antidepressant (SPRAVATO® is used alongside standard medications)

Please note that SPRAVATO® is not recommended for individuals with uncontrolled high blood pressure or certain medical conditions. Specialists at NeuroHealth Treatment Centers will evaluate your medical history to determine if SPRAVATO® is right for you.

What to Expect During SPRAVATO® Treatment

Many patients feel nervous about starting a new treatment, so here’s what to expect during your SPRAVATO® journey at NeuroHealth Treatment Centers:

1. Initial Consultation: We’ll assess your symptoms, medical history, and prior treatments to determine eligibility.
2. First Treatment Session: You’ll self-administer the nasal spray under medical supervision.
3. Observation Period: You’ll rest in our calm, private treatment room for about two hours, during which we monitor your blood pressure and ensure you are not experiencing any adverse effects.
4. Ongoing Treatments: The initial phase includes twice-weekly treatments for four weeks, followed by less frequent maintenance sessions.

After each session, you cannot drive for the rest of the day, so you’ll need someone to take you home.

Benefits of SPRAVATO® Therapy

SPRAVATO® offers a breakthrough solution for individuals struggling with severe, treatment-resistant depression. Unlike traditional antidepressants, which can take weeks or even months to show results, SPRAVATO® is designed to work rapidly, offering relief for patients who need immediate intervention.

For many, SPRAVATO® is a lifeline to hope and healing, helping to reduce symptoms and improve quality of life in a way that other treatments have not. Below are some of the key benefits of SPRAVATO® therapy:

• Rapid symptom relief – Many patients notice improvements in mood, energy, and clarity within the first few sessions.
• Effective for severe depression – Helps those who haven’t responded to standard antidepressants.
• Reduces suicidal thoughts – SPRAVATO® is one of the only FDA-approved treatments for suicidal depression.
• Long-lasting effects – With continued treatment, many patients experience sustained relief from depressive symptoms.

Is SPRAVATO® Safe?

SPRAVATO® is FDA-approved and considered safe when administered in a certified medical setting. However, it is important to be aware of the following:

• Temporary side effects: Dizziness, nausea, increased blood pressure, or mild dissociation are commonly reported side effects.
• Dissociation effects: Some patients describe feeling “out of body” or detached during treatment, but this effect is temporary and closely monitored.
• Strict safety protocols: Patients must remain at the clinic for two hours after treatment to ensure their safety. They also cannot operate a vehicle after the treatment is administered, so it is important to plan ahead and make arrangements.

Our trained medical staff ensures a safe, comfortable experience every step of the way.

Making Treatment Accessible

Covered by Most Insurance Plans

How to Get Started with SPRAVATO® at NeuroHealth Treatment Centers

If you’re interested in SPRAVATO® therapy, we’ll guide you through insurance approval, treatment planning, and ongoing care.

Step 1: Schedule a FREE Consultation

We’ll evaluate your depression history and discuss treatment options.

Step 2: Insurance & Approval Process

Our team will help navigate insurance coverage and pre-authorization. Many insurance plans cover SPRAVATO®, and we’ll work with your provider to determine eligibility.

Step 3: Begin Treatment

Start your personalized SPRAVATO® plan under expert supervision.

Why Choose NeuroHealth Treatment Centers for SPRAVATO® Therapy?

Choosing the right treatment center is an important step in your journey toward healing. At NeuroHealth Treatment Centers, we go beyond just offering SPRAVATO® therapy—we provide a comprehensive, patient-focused approach designed to ensure you receive the best possible care.

From personalized treatment plans to a compassionate and experienced medical team, we are dedicated to helping you find relief and regain control of your life. Here’s why so many patients trust us with their mental health care:

• Expert psychiatric specialists – Our team has extensive experience in treating severe depression.
• State-of-the-art treatment facility – A calm, private environment designed for comfort and healing.
• Personalized care – Every patient receives a customized treatment plan for the best outcomes.
• Insurance assistance – We help you navigate insurance approval and financing options.

Your mental health matters—we’re here to help you find relief and recovery. SPRAVATO® may be combined with transcranial magnetic stimulation (TMS) therapy to amplify relief for treatment-resistant depression and major depressive disorder.

Frequently Asked Questions About SPRAVATO® Therapy

How soon will I feel relief with SPRAVATO®?

Many patients report feeling improvements within hours to days after the first few treatments.

How is SPRAVATO® different from ketamine infusions?

SPRAVATO® is an FDA-approved, nasal spray version of ketamine, whereas IV ketamine infusions are an off-label treatment.

Will my insurance cover SPRAVATO®?

Many insurance plans do cover SPRAVATO®, but coverage varies. We can check your benefits and help with the approval process.

Is SPRAVATO® addictive?

When used in a medical setting under supervision, SPRAVATO® has a low risk of dependence.

What should I do after treatment?

You’ll need a ride home and should rest for the remainder of the day. Avoid driving or operating heavy machinery.

SPRAVATO® Therapy – Take the First Step Toward Relief

If you’re struggling with treatment-resistant depression or major depressive disorder with suicidal thoughts, don’t lose hope. SPRAVATO® may help you regain control of your life.

NeuroHealth Treatment Centers is committed to helping patients transform their lives through innovative depression treatments. Our goal is to make treatment accessible and customize mental health care for each patient’s individual needs.

Find out if SPRAVATO® therapy is right for you. Call 954-417-7575 today or contact us online to book a FREE consultation. NeuroHealth Treatment Centers serves patients in Fort Lauderdale and all of South Florida.